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Molecular Pharmacology Fast Forward
First published on March 7, 2008; DOI: 10.1124/mol.108.046961

0026-895X/08/7306-1589-1591$20.00
Mol Pharmacol 73:1589-1591, 2008

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Perspective

Making the T-Type Even Tinier: Corticotropin-Releasing Factor-Mediated Inhibition of Low-Voltage-Activated Calcium Channel Activity

Diego L. Varela, Tamara Hermosilla, and Gerald W. Zamponi

Hotchkiss Brain Institute, Departments of Physiology & Biophysics, Pharmacology & Therapeutics, and Cell Biology & Anatomy, University of Calgary, Calgary, Canada

T-type calcium channels are important for a variety of physiological processes such as brain and heart function. Proper regulation of these channels by second messengers is fundamental; however, our knowledge of the molecular pathways that regulate T-type calcium channels is limited in comparison with other voltage-dependent calcium channels. In this issue of Molecular Pharmacology, Tao et al. (p. 1596) demonstrate that Cav3.2 is regulated by activation of the corticotropin-releasing factor receptor 1 in a Gβ{gamma}-dependent manner.

Received for publication March 4, 2008.

Accepted for publication March 7, 2008.

Address correspondence to: Dr. Gerald W. Zamponi, Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr. NW, Calgary, T2N 4N1, Canada. E-mail: zamponi{at}ucalgary.ca


Related articles in MolPharm:

Activation of Corticotropin-Releasing Factor Receptor 1 Selectively Inhibits CaV3.2 T-Type Calcium Channels
Jin Tao, Michael E. Hildebrand, Ping Liao, Mui Cheng Liang, Gregory Tan, Shengnan Li, Terrance P. Snutch, and Tuck Wah Soong
MolPharm 2008 73: 1596-1609. [Abstract] [Full Text]  





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