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Regulation of the Mammalian Nervous System by MicroRNAs

Department of Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota

The mammalian nervous system exerts essential control on many physiological processes in the organism and is itself controlled extensively by a variety of genetic regulatory mechanisms. MicroRNAs, a class of small, noncoding RNAs, are critical contributors to the regulation of gene expression in the nervous system. Emerging evidence indicates that microRNAs regulate both the development and function of the nervous system. Deficiency in microRNA function has also been implicated in a number of neurological disorders. Understanding the roles of microRNAs will provide new insights into the complexity and operation of the nervous system.

Received for publication September 17, 2008.

Accepted for publication November 12, 2008.

Address correspondence to: Dr. Yan Zeng, 6-120 Jackson Hall, 321 Church Street SE, Department of Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455. E-mail: zengx033{at}umn.edu.