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Molecular Pharmacology, Vol 8, 104-109, Copyright © 1972 by the American Society for Pharmacology and Experimental Therapeutics

Binding and Circular Dichroism Studies on Interactions of Lysergic Acid Diethylamide with Deoxyribonucleic Acid

C. A. BUSH 1, A. PESCE 1, M. GAIZUTIS 1, and V. NAIR 1

1 Chemistry Department, Illinois Institute of Technology; Departments of Medicine, Michael Reese Hospital and Medical Center and University of Chicago, Pritzker School of Medicine: and Institute of Psychiatry, Michael Reese Hospital, and Department of Pharmacology, Chicago Medical School, Chicago, Illinois 60612

The interactions of d- and l-lysergic acid diethylamide (LSD) with DNA were studied by means of equilibrium dialysis and circular dichroism. There was no significant difference between the binidinig of d- and l-LSD to DNA. Circular dichroism data do not favor intercalation, and it is suggested that LSD is probably bound outside the DNA helix, perhaps to the phosphate groups of DNA by some ionic mechanism.

Note:
ACKNOWLEDGMENT We thank Professor Irving Klotz, Northwestern University, for helpful comments and Messrs. D. Bau and S. Siegel for technical assistance.

Submitted on June 28, 1971






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