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Molecular Pharmacology, Vol 8, 249-255, Copyright © 1972 by the American Society for Pharmacology and Experimental Therapeutics

Evidence for a Ternary Complex Containing Albumin, Copper, and Penicillamine

YUKIO SUGIURA 1 and HISASHI TANAKA 1

1 Laboratory of Pharmaceutical Radiochemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Shimoadachi-cho, Sakyo-ku, Kyoto, Japan

The interaction between penicillamine and albumin-bound copper has been investigated. The presence of a ternary complex involving albumin, copper and penicillamine as an intermediate step in the course of the removal of copper has been demonstrated by gel filtration technique with [3H]penicillamine and 64Cu. Copper is presumed to exist in the complex in both the cupric and cuprous states. These findings suggest a mechanism for the migration of copper from the albumin—copper(II) complex to penicillamine, and explain the unique reductive chelating action of penicillamine in the treatment of Wilson's disease.

Submitted on October 22, 1971






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