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Molecular Pharmacology, Vol 8, 264-267, Copyright © 1972 by the American Society for Pharmacology and Experimental Therapeutics

Inhibition by Colchicine and by Vinblastine of Acetylcholine-Induced Catecholamine Release from the Adrenal Gland: an Anticholinergic Action, Not an Effect upon Microtubules

J. M. TRIFARÓ 1, B. COLLIER 1, A. LASTOWECKA 1, and D. STERN 1

1 Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada

We have confirmed that colchicine (1 mM) or vinblastine (100 µM) inhibits the acetylcholine-induced release of catecholamines from perfused bovine adrenal glands. This is an anticholinergic effect of these drugs and cannot be interpreted as evidence that microtubules participate in the release of amines, because neither colchicine nor vinblastine reduced catecholamine released by a high concentration of K+ or by angiotensin. Furthermore, both colchicine (1 mM) and vinblastine (100 µM) blocked transmission through the superior cervical ganglion of the cat by a postsynaptic anti-acetylcholine action.

Submitted on November 29, 1971




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A. Taylor, M. Mamelak, E. Reaven, and R. Maffly
Vasopressin: Possible Role of Microtubules and Microfilaments in Its Action
Science, July 27, 1973; 181(4097): 347 - 350.
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