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Molecular Pharmacology, Vol 8, 311-317, Copyright © 1972 by the American Society for Pharmacology and Experimental Therapeutics

The Enzymatic Formation of Methanol from S-Adenosylmethionine by Various Tissues of the Rat

ROLAND D. CIARANELLO 1, HANS J. DANKERS 1, and JACK D. BARCHAS 1

1 Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305

An enzyme which forms methanol from S-adenosylmethionine is demonstrated to be present in a variety of mammalian tissues. That one of the products is methanol was determined by two means: (a) crystallization as [methyl]dinitrobenzoate, and (b) synthesis of 35S-labeled S-adenosylmethionine and demonstration that 35S was not incorporated into the volatile product. Highest levels of enzyme activity are found in the pituitary and hypothalamus. Other areas which contain the enzyme include brain, kidney, liver, lung, and heart. The enzyme from brain has a Km of 2.5 µM for S-adenosylmethionine. Enzyme activity is found predominantly in the supernatant fraction of brain homogenates.

Submitted on January 31, 1972




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R. Wyatt, E Erdelyi, DoAmaral JR, G. Elliott, J Renson, and J. Barchas
Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine
Science, March 7, 1975; 187(4179): 853 - 855.
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