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Molecular Pharmacology, Vol 8, 531-537, Copyright © 1972 by the American Society for Pharmacology and Experimental Therapeutics

Release of Free Bases from Deoxyribonucleic Acid after Reaction with Bleomycin

CHARLES W. HAIDLE 1, K. KAY WEISS 1, and M. TIEN KUO 1

1 Section of Molecular Biology, The University of Texas at Houston, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025

Labeled free bases could be detected chromatographically after reaction of deoxyribonucleic acid with high concentrations of the antibiotic bleomycin. Thymine, adenine, guanine, and cytosine were released from DNAs previously labeled in the base moiety with each of the four bases. No detectable amounts of nucleosides, nucleotides, deoxyribose, deoxyribose phosphate, or inorganic phosphate were released.

Note:
ACKNOWLEDGMENTS The authors with to thank Mrs. Elsie Jackson for her excellent technical assistance, and to express appreciation to Dr. L. Daniel Inners for his assistance in the molecular weight determination.

Submitted on February 25, 1972






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