MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BAKER, R. W.
Right arrow Articles by WEBER, H. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BAKER, R. W.
Right arrow Articles by WEBER, H. P.

Molecular Pharmacology, Vol 9, 23-32, Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics

Molecular Structures of Hallucinogenic Substances: Lysergic Acid Diethylamide, Psilocybin, and 2,4,5-Trimethoxyamphetamine

ROY W. BAKER 1, CYRUS CHOTHIA 1, PETER PAULING 1, and HANS PETER WEBER 2

1 William Ramsay, Ralph Forster, and Christopher Ingold Laboratories, University College, London WC1, England
2 Research Laboratories for Pharmaceutical Chemistry, Sandoz, Ltd., Basel, Switzerland

X-ray diffraction structure analyses of the hallucinogenic substances lysergic acid diethylamide o-iodobenzoate monohydrate, N,N-dimethyl-4-phosphoryloxytryptamine monoethanolate (psilocybin), and 2,4,5-trimethoxyamphetamine hydrochloride are reported. They reveal some relationships among the relative structural arrangements of possible pharmacodynamic groups of these substances.

Note:
ACKNOWLEDGMENTS We thank Drs. A. Hofmann and A. T. Shulgin for crystalline samples, Dr. Trevor J. Petcher and Dr. Göran Falkenberg for useful discussion, Miss Margaret Dellow for programming assistance, Professor D. Carlström, Dr. R. Bergin, Dr. G. Falkenberg, Dr. Pamela M. Bailey, Professor K. Tomita, and Dr. G. Tsoucaris for communication of their results in advance of publication, Miss Patricia Brennan for assistance, and Mr. John Cresswell for the drawings.

Submitted on May 26, 1972






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics