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Molecular Pharmacology, Vol 9, 247-258, Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics

Effects of Phenobarbital and 3-Methylcholanthrene on Amino Acid Incorporation into Rat Liver Chromosomal Proteins

JIM BLANKENSHIP 1 and LEROY KUEHL 1

1 Departments of Pharmacology and Biochemistry, University of Utah College of Medicine, Salt Lake City, Utah 84112

The effects of phenobarbital and 3-methylcholanthrene on amino acid incorporation into rat liver chromosomal proteins in vivo were studied. Although both drugs stimulated incorporation into histones and non-histone chromosomal proteins, the results of dual-isotope experiments revealed that the increases were not selective for any of the major non-histone chromosomal protein fractions. Rather, incorporation into all these fractions was apparently stimulated uniformly. This nonselective stimulation of incorporation may reflect drug-induced increases in amino acid incorporation preceding mitotic activity and liver growth.

Submitted on November 13, 1972






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