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Molecular Pharmacology, Vol 9, 311-319, Copyright © 1973 by the American Society for Pharmacology and Experimental Therapeutics

Uptake of 5-Hydroxytryptamine by Schistosoma mansoni

JAMES L. BENNETT 1 and ERNEST BUEDING 1

1 Department of Pathobiology, School of Hygiene and Public Health, and Department of Pharmacology and Experimental Therapeutics, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205

In spite of the presence of high concentrations of 5-hydroxytryptamine (5-HT) in Schistosoma mansoni, synthesis of this amine by the parasite could not be demonstrated. The worm has a high- and a low-affinity uptake mechanism (below and above 2 µM, respectively) for 5-HT. The high-affinity uptake mechanism provides the parasite with a means to obtain 5-HT, even at the low concentrations of this amine prevailing in the physiological environment of the worm.

Note:
ACKNOWLEDGMENT We are indebted to Dr. A. H. Glässer of Farmitalia for the 8beta[(carbobenzoxyamino)methyl]-1,6-dimethyl-l0agr-ergotine used in this study.

Submitted on December 12, 1972




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