Data Supplement

Files in this Data Supplement:

• Data Supplement - This supplement contains:

  Supplemental Table 1. Values of rate constants used for modeling P2X3 receptor kinetics in the presence of ATP, α,β-meATP, β,γ-meATP, or 2-Me-SATP

  Supplemental File 1. Mathematical approaches to fitting the process of recovery from desensitization.

  Supplemental Figure 1. Recovery from desensitization can be fitted with sigmoidal timecourse depending on number of receptor states, assuming independence of agonist-bound sites.

  Supplemental Figure 2. Preliminary screening of kinetic models for desensitization of the P2X3 receptor.

  Supplemental Figure 3. Pharmacological properties of P2X3 receptors of TG mouse neurons.

  Supplemental Figure 4. Agonist-dependent characteristics of HAD on native P2X3 receptors of rat DRG neurons, and their comparison with recombinant rP2X3 receptors expressed in HEK293T cells.