Data Supplement

Files in this Data Supplement:

• Data Supplement - This supplement contains:

  Figure S1. Time-dependent efficacy of Ret-acetamide in inhibition of the chromophore production.

  Figure S2. Efficacy at peak blood concentration of Ret-acetamide treatment.

  Figure S3. The effect of multiple gavages of Ret-NH2 on retinoid levels in the eye, body weight, and visual responses.

  Figure S4. A long-term suppression of 11-cis-retinal production by Ret-NH2.

  Figure S5. Analysis of protein levels by immunoblotting.

  Table 1, supplement. The largest changes in gene expression after retinoid treatment in the liver.

  Table 2, supplement. The largest changes in gene expression after retinoid treatment in the eye.