Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to "In Vivo" Biological Activity
Mol Pharmacol Lemaire et al.
72: 572
Data Supplement
Files in this Data Supplement:
Data Supplement
-
Figure 1. Position of rifampicin in the ligand binding pocket of hPXR...
Data Supplement
-
Figure 2. Table A, Set I. Docking results of compounds described in this manuscript.
Table B. Set II. Docking results of 10 additional compounds...
Data Supplement
-
Figure 3. C2B4-A is an efficient hPXR agonist...
Data Supplement
-
Figure 4. Effect of C2B4-A on an in vivo induction of hPXR in nude mice...