Data Supplement

Files in this Data Supplement:

• Data Supplement -
  SUPPLEMENTARY TABLE 1. Effects of the mutations on the expression levels of the M1 mAChR, and its affinities for (-)-N-methyl scopolamine and (-)-3-quinuclidinyl benzilate.

  SUPPLEMENTARY TABLE 2. Effects of the mutations of the M1 mAChR on the binding properties of acetylcholine.

  SUPPLEMENTARY TABLE 3. Effects of the mutations of the M1 mAChR on the phosphoinositide signalling response.

  SUPPLEMENTARY TABLE 4. Effects of the mutations of the M1 mAChR on the dissociation kinetics of (-)-N-methyl scopolamine and (-)-3-quinuclidinyl benzilate.

  SUPPLEMENTARY TABLE 5. Summary of effects of binding site mutations on NMS, QNB and ACh Affinity.