Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)
Mol Pharmacol Xu et al.
73: 1709
Data Supplement
This article contains three data supplements.
Files in this Data Supplement:
Supplement 1 -
Confirmation of PD307243 structure.
Supplement 2 -
Time control of the hERG current amplitude recorded using the static bath conditions.
Supplement 3 -
Positions on the Outer Vestibule of the hERG Channel Where Side Chain Substitution by cysteine or modification of the engineered cysteine side chain impaired the agonist effect of NS1643.
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
