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Received for publication November 15, 2004.
Revised January 6, 2005.
Accepted for publication January 6, 2005.
The application of microarray technology to characterize changes in global gene expression in response to chemical exposure holds great promise for toxicant classification and hazard prediction. Unfortunately, the use of different array platforms, different hybridization protocols and different annotation schemes hinders the meaningful comparison of transcriptional profiling data across laboratories. Our solution to this problem is to centralize microarray data generation and to develop easily accessible and uniform informatic tools for the efficient analysis and sharing of toxicogenomic data. In an effort to create such a resource, we developed a standardized set of microarray reagents and reproducible protocols for the analysis of liver gene expression in the mouse model. Moreover, we have generated an initial training set of 117 toxicogenomic profiles. This web-accessible database and informatics suite, known as Environment, Drugs, Genes and Expression, or EDGE, is now available at http://edge.oncology.wisc.edu/edge.php.
Key words:
Pharmacogenomic analyses, Regulation of gene expression, Regulation - transcriptional, Regulation - xenobiotic, Toxicant-induced gene express
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