MolPharm

Home Help [Feedback] [For Subscribers] [Archive] [Search] --
QUICK SEARCH:   [advanced]


     

Molecular Pharmacology Fast Forward
First published on February 15, 2005; DOI: 10.1124/mol.105.011288

This Article
Right arrow Full Text (PDF)
Right arrow Related Article
Right arrow All Versions of this Article:
mol.105.011288v1
67/5/1388    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Trejo, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Trejo, J.


Received for publication January 20, 2005.
Revised January 19, 2005.
Accepted for publication January 25, 2005.

Internal PDZ ligands: Novel Endocytic Recycling Motifs for G Protein-Coupled Receptors (Relates to Article by Paasche, et al., FastForward 15 February 2005)

JoAnn Trejo 1*

1 University of North Carolina at Chapel Hill

* Address correspondence to: E-mail: joann_trejo{at}med.unc.edu

Abstract

Internalization, recycling and lysosomal sorting are key processes that regulate the temporal and spatial signaling of G protein-coupled receptors (GPCRs). Interactions between GPCR intracytosolic sorting signals and adaptor proteins facilitate trafficking through the endocytic pathway. To date only a few sorting signals and molecules that regulate GPCR trafficking have been identified. A study in this issue of Molecular Pharmacology has now identified an internal PDZ ligand motif that appears to regulate efficient recycling of the ETA endothelin receptor. This finding now expands the diversity of GPCR sorting motifs to include internal and C-terminal PDZ ligands, tyrosine-based motifs and lysine residues capable of being ubiquitinated.


Key words: Endothelin, Receptor synthesis/trafficking, Desensitization/uncoupling, Sequestration/Internalization, GRKs, barrestins, Phosphorylation/Dephosphorylation, Receptor degradation, Recycling


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
P. J. Baugher and A. Richmond
The Carboxyl-terminal PDZ Ligand Motif of Chemokine Receptor CXCR2 Modulates Post-endocytic Sorting and Cellular Chemotaxis
J. Biol. Chem., November 7, 2008; 283(45): 30868 - 30878.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. Delhaye, A. Gravot, D. Ayinde, F. Niedergang, M. Alizon, and A. Brelot
Identification of a Postendocytic Sorting Sequence in CCR5
Mol. Pharmacol., December 1, 2007; 72(6): 1497 - 1507.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ.
Physiol Rev, October 1, 2006; 86(4): 1309 - 1379.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] --
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 2005 by the American Society for Pharmacology and Experimental Therapeutics