![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
|
|
|
|
|
||
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Received for publication April 26, 2005.
Revised July 1, 2005.
Accepted for publication July 28, 2005.
Activation of group I metabotropic glutamate (mGlu)
receptors drives the endocannabinoid system to cause
both short- and long-term changes of synaptic strength
in the striatum, hippocampus and other brain areas.
Although there is strong electrophysiological evidence
for a role of endocannabinoid release in mGlu receptors-
dependent plasticity, the identity of the
endocannabinoid transmitter mediating this phenomenon
remains undefined. Here we show that activation of group
I mGlu receptors triggers the biosynthesis of the
endocannabinoid 2-arachidonoylglycerol (2-AG), but not
anandamide, in primary cultures of corticostriatal and
hippocampal slices prepared from early postnatal rat
brain. Pharmacological studies suggest that 2-AG
biosynthesis is initiated by activation of mGlu5
receptors, is catalyzed by phospholipase C (PLC) and 1,2-
diacylglycerol lipase (DGL) activities, and is dependent
on intracellular Ca2+ ions. Real-time PCR and
immunostaining analyses indicate that DGL-
is the
predominant DGL isoform expressed in corticostriatal and
hippocampal slices and that this enzyme is highly
expressed in striatal neurons, where it is colocalized
with PLC-1. The results suggest that 2-AG is a
primary endocannabinoid mediator of mGlu receptor-
dependent neuronal plasticity.
Key words:
Cannabinoid, Metabotropic glutamate, Synaptic plasticity
This article has been cited by other articles:
|
|
 |
|
  B. Pan, W. Wang, J. Z. Long, D. Sun, C. J. Hillard, B. F. Cravatt, and Q.-s. Liu Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling J. Pharmacol. Exp. Ther., November 1, 2009; 331(2): 591 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Won, H. L. Puhl III, and S. R. Ikeda Molecular Reconstruction of mGluR5a-Mediated Endocannabinoid Signaling Cascade in Single Rat Sympathetic Neurons J. Neurosci., October 28, 2009; 29(43): 13603 - 13612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Drew, B. K. Lau, and C. W. Vaughan Substance P Drives Endocannabinoid-Mediated Disinhibition in a Midbrain Descending Analgesic Pathway J. Neurosci., June 3, 2009; 29(22): 7220 - 7229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kano, T. Ohno-Shosaku, Y. Hashimotodani, M. Uchigashima, and M. Watanabe Endocannabinoid-Mediated Control of Synaptic Transmission Physiol Rev, January 1, 2009; 89(1): 309 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pan, C. J. Hillard, and Q.-s. Liu D2 Dopamine Receptor Activation Facilitates Endocannabinoid-Mediated Long-Term Synaptic Depression of GABAergic Synaptic Transmission in Midbrain Dopamine Neurons via cAMP-Protein Kinase A Signaling J. Neurosci., December 24, 2008; 28(52): 14018 - 14030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Marinelli, S. Pacioni, T. Bisogno, V. Di Marzo, D. A. Prince, J. R. Huguenard, and A. Bacci The Endocannabinoid 2-Arachidonoylglycerol Is Responsible for the Slow Self-Inhibition in Neocortical Interneurons J. Neurosci., December 10, 2008; 28(50): 13532 - 13541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sheinin, G. Talani, M. I. Davis, and D. M. Lovinger Endocannabinoid- and mGluR5-Dependent Short-Term Synaptic Depression in an Isolated Neuron/Bouton Preparation From the Hippocampal CA1 Region J Neurophysiol, August 1, 2008; 100(2): 1041 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rossi, V. De Chiara, A. Musella, H. Kusayanagi, G. Mataluni, G. Bernardi, A. Usiello, and D. Centonze Chronic Psychoemotional Stress Impairs Cannabinoid-Receptor-Mediated Control of GABA Transmission in the Striatum J. Neurosci., July 16, 2008; 28(29): 7284 - 7292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Edwards, L. Zhang, and B. E. Alger Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus PNAS, June 10, 2008; 105(23): 8142 - 8147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pan, C. J. Hillard, and Q.-s. Liu Endocannabinoid Signaling Mediates Cocaine-Induced Inhibitory Synaptic Plasticity in Midbrain Dopamine Neurons J. Neurosci., February 6, 2008; 28(6): 1385 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Drew, V. A. Mitchell, and C. W. Vaughan Glutamate Spillover Modulates GABAergic Synaptic Transmission in the Rat Midbrain Periaqueductal Grey via Metabotropic Glutamate Receptors and Endocannabinoid Signaling J. Neurosci., January 23, 2008; 28(4): 808 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.H. Taylor, C. Ang, S.C. Bell, and J.C. Konje The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy Hum. Reprod. Update, September 1, 2007; 13(5): 501 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-M. Jung, G. Astarita, C. Zhu, M. Wallace, K. Mackie, and D. Piomelli A Key Role for Diacylglycerol Lipase-{alpha} in Metabotropic Glutamate Receptor-Dependent Endocannabinoid Mobilization Mol. Pharmacol., September 1, 2007; 72(3): 612 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Oka, S. Arai, K. Waku, A. Tokumura, and T. Sugiura Depolarization-induced Rapid Generation of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, in Rat Brain Synaptosomes J. Biochem., May 1, 2007; 141(5): 687 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hashimotodani, T. Ohno-Shosaku, and M. Kano Endocannabinoids and Synaptic Function in the CNS Neuroscientist, April 1, 2007; 13(2): 127 - 137. [Abstract] [PDF]
|
|
|
|
 |
|
 B. Szabo, M. J. Urbanski, T. Bisogno, V. D. Marzo, A. Mendiguren, W. U. Baer, and I. Freiman Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol J. Physiol., November 15, 2006; 577(1): 263 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Katona, G. M. Urban, M. Wallace, C. Ledent, K.-M. Jung, D. Piomelli, K. Mackie, and T. F. Freund Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses J. Neurosci., May 24, 2006; 26(21): 5628 - 5637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Yin and D. M. Lovinger Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling PNAS, May 23, 2006; 103(21): 8251 - 8256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Isokawa and B. E. Alger Ryanodine Receptor Regulates Endogenous Cannabinoid Mobilization in the Hippocampus J Neurophysiol, May 1, 2006; 95(5): 3001 - 3011. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
