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Molecular Pharmacology Fast Forward
First published on May 23, 2005; DOI: 10.1124/mol.105.014951

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Received for publication May 20, 2005.
Revised May 20, 2005.
Accepted for publication May 23, 2005.

How the Monoamine Transporter Garden Grows (Relates to Article by Hahn, et al. FastForward 13 May 2005)

Arnold E. Ruoho 1*

1 University of Wisconsin Medical School

* Address correspondence to: E-mail: aeruoho{at}wisc.edu

Abstract

In this issue of Molecular Pharmacology, Hahn, Mazei-Robison and Blakely present a study of previously uncharacterized single amino acid variants of the human norepinephrine transporter (hNET). Intracellular trafficking, surface expression, transport properties, interaction with antagonists and regulation by a protein kinase C (PKC) linked regulatory pathway were studied by heterologous expression in COS-7 cells. In recent years, there has been increasing focus on the natural variations and roles of nonsynonymous single nucleotide polymorphisms (SNPs) in human membrane transporter genes (and their protein products) in human disease. As this information is assimilated and understood at the molecular and genetic level, the relationship between transporter pharmacogenomics and therapeutics in the age of individualized medicine will be greatly impacted.


Key words: Adrenergic, Protein Kinase C, Biogenic Amine, Pharmacogenomic analyses




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