Received for publication October 21, 2005.
Revised October 21, 2005.
Accepted for publication October 21, 2005.

The _1D-adrenergic receptor: Cinderella or ugly stepsister (Relates to Article by Hague, et al. FastForward 29 September 2005)

Abstract

This Perspective focuses on the _1D- adrenergic receptor (AR), the often neglected sibling of the ₁-AR family. This neglect is in part due to its poor cell-surface expression. However, it has recently been shown that dimerization of the & [alpha]_1D-AR with either the _1B-AR or the ₂-AR increases _1D-AR cell-surface expression and in this issue of Molecular Pharmacology, Hague et al. demonstrate that dimerization of the _1D-AR with the _1B-AR not only leads to increased cell-surface expression but also results in the formation of a novel functional entity.

Key words: Adrenergic, Receptor synthesis/trafficking