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First published on June 7, 2006; DOI: 10.1124/mol.106.026104

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Received for publication April 27, 2006.
Revised June 6, 2006.
Accepted for publication June 6, 2006.

Pharmacological targeting of adipocytes/fat metabolism for treatment of obesity and diabetes

Paul F Pilch 1* Nils Bergenhem 2

1 Boston University School of Medicine 2 Adipogenix

* Address correspondence to: E-mail: ppilch{at}bu.edu

Abstract

Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes. Thus, considerable efforts are underway in the pharmaceutical industry to find drugs to treat this condition. Target validation in various academic and industrial laboratories has revealed a number of potential molecular targets in fat cells or adipocytes. By definition, obesity is too much fat and here we review efforts to treat obesity, and by proxy diabetes, by modulating the metabolic state of adipocytes.


Key words: Regulation - physiological, Endocrine cells




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