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First published on May 25, 2006; DOI: 10.1124/mol.106.026914

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Received for publication May 22, 2006.
Revised May 22, 2006.
Accepted for publication May 25, 2006.

Pharmacology Meets Vesicular Trafficking at a CNS Synapse: Pregabalin Effects on Synaptic Vesicle Cycling in Hippocampal Neurons

Ronald W Holz 1*

1 University of Michigan School of Medicine

* Address correspondence to: E-mail: holz{at}umich.edu

Abstract

The contribution by Micheva et al., (2006) in the current issue adds to our understanding of the action of pregabalin, a drug used for treatment of partial seizures and neuropathic pain. The authors examine the effects of pregabalin on presynaptic function of cultured hippocampal neurons using a powerful technique to follow the trafficking of synaptic vesicles in individual boutons. The study revealed that pregabalin reduces the readily releasable pool of synaptic vesicles in an NMDA receptor-dependent manner.


Key words: Glutamate, Synaptic plasticity




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