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First published on February 27, 2007; DOI: 10.1124/mol.106.033118

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Received for publication November 29, 2006.
Revised February 13, 2007.
Accepted for publication February 27, 2007.

Rimonabant: Just an Anti-obesity Drug? Current Evidence on Its Pleiotropic Effects

Maurizio Bifulco 1*, Claudia Grimaldi 1, Patrizia Gazzerro 1, Simona Pisanti 1, Antonietta Santoro 1

1 University of Salerno

* Address correspondence to: E-mail: maubiful{at}unina.it

Abstract

The advent of the highly selective cannabinoid receptor (CB1) antagonist, rimonabant (SR141716, AcompliaTM) can revolutionize the ability of the clinicians to manage obesity. Large-scale clinical trials have demonstrated that rimonabant therapy can reduce obesity. Although, the precise mechanisms of action of rimonabant have to be further dissected, it is emerging, from both pre-clinical and clinical research, that rimonabant is not only an anti-obesity drug but its pleiotropic functions affect a broad range of diseases, from obesity related co-morbidities to drug dependence and cancer. Here we review recent data from the literature and discuss the full pharmacological potential of this drug.


Key words: Cannabinoid, Receptor-mediated, Cholesterol metabolism/lipoproteins


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