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Molecular Pharmacology Fast Forward
First published on December 19, 2006; DOI: 10.1124/mol.106.033266

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Received for publication December 12, 2006.
Revised December 6, 2006.
Accepted for publication December 19, 2006.

DNA (cytosine-5) Methyltransferase Inhibitors: A Potential Therapeutic for Schizophrenia (Relates to article by Kundakovic, et al., Fast Forward 25 October 2006)

Jonathan M Levenson 1*

1 University of Wisconsin

* Address correspondence to: E-mail: jlevenson{at}wisc.edu

Abstract

In this issue of Molecular Pharmacology, Kundakovic et al. present compelling evidence suggesting that the promoters for reelin and GAD67 are coordinately regulated. The regulation occurs at the level of DNA (cytosine-5) methylation. Moreover, the authors present evidence that suggests pharmacologic inhibition of DNA methyltransferase results in reversal of methylation, loss of methyl-DNA binding proteins and relief of repression. Repression of both reelin and GAD67 have been implicated in the pathogenesis of Schizophrenia. Therefore, these results suggest that the reelin and GAD67 promoters are subject to continuous repression by DNA methyltransferase, and that inhibitors of DNA methyltransferase represent a potential treatment for Schizophrenia.


Key words: Regulation - transcriptional, Anti-psychotics


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[Abstract] [Full Text] [PDF]


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