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Molecular Pharmacology Fast Forward
First published on February 15, 2007; DOI: 10.1124/mol.107.035196

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Received for publication February 15, 2007.
Revised February 13, 2007.
Accepted for publication February 15, 2007.

The thrill can kill: Murder by methylation (Relates to article by Zhang, et al., Fast Forward 3 January 2007)

Sailen Barik 1*

1 University of South Alabama

* Address correspondence to: E-mail: sbarik{at}jaguar1.usouthal.edu

Abstract

Why babies of crack-cocaine mothers develop heart problems has always been a mystery. In this issue of Molecular Pharmacology, Zhang et al (p. XX) show that a specific methylation occurs at the protein kinase C epsilon (PKC{epsilon}) promoter of the babies born of mother rats exposed to cocaine. This reduces the expression of PKC{epsilon}, a naturally cardioprotective enzyme, which provides a plausible molecular mechanism for cardiac failure.


Key words: Dopamine, Protein Kinase C, AP-1, Promoter analysis, Regulation - transcriptional, Apoptosis, Toxicant-induced gene express, Cocaine, Ischemia/Reperfusion




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