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Received for publication April 19, 2007.
Revised May 24, 2007.
Accepted for publication May 29, 2007.
For over thirty years, the aryl hydrocarbon receptor (AHR, Ah receptor) has been extensively scrutinized as the cellular receptor for numerous environmental contaminants, including dioxins, dibenzofurans and polychlorinated biphenyls (PCBs). Recent evidence argues that this description is incomplete and, perhaps, myopic. Ah receptor orthologs have been demonstrated to mediate diverse endogenous functions in our close vertebrate relatives as well as our distant invertebrate ancestors. Moreover, these endogenous functions suggest that xenobiotic toxicity may be best understood in the context of intrinsic AHR physiology. In this literature review, we survey the emerging picture of endogenous AHR biology from work in the vertebrate and invertebrate model systems Mus musculus, Caenorhabditis elegans, and Drosophila melanogaster.
Key words:
Transcriptional coactivators, Cytochrome P450, Ah receptor, Genetics
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