MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] --
QUICK SEARCH:   [advanced]


     

Molecular Pharmacology Fast Forward
First published on May 23, 2007; DOI: 10.1124/mol.107.038232

This Article
Right arrow Full Text (PDF)
Right arrow Related Article
Right arrow All Versions of this Article:
mol.107.038232v1
72/2/235    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Monfils, M. H
Right arrow Articles by LeDoux, J. E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Monfils, M. H
Right arrow Articles by LeDoux, J. E


Received for publication May 17, 2007.
Revised May 17, 2007.
Accepted for publication May 23, 2007.

BDNF: linking fear learning to memory consolidation (Relates to article by Ou & Gean, Fast Forward 24 April 2007)

Marie H Monfils 1*, Kiriana K Cowansage 1, Joseph E LeDoux 1

1 New York University

* Address correspondence to: E-mail: monfils{at}cns.nyu.edu

Abstract

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays an important role in synaptic plasticity. In this issue of Molecular Pharmacology, Ou & Gean thoroughly describe the molecular cascade by which fear learning leads to an increase in BDNF expression in the lateral amygdala (LA). Calcium influx through NMDA receptors and L-VDCC channels, which occurs in the LA during fear conditioning, activates PKA and CaMKIV. Each induces phosphorylation of CREB, which binds to the BDNF promoter, leading to BDNF expression in the LA, and contributes to fear memory consolidation.


Key words: Protein Kinase A, Synaptic plasticity




Home Help [Feedback] [For Subscribers] [Archive] [Search] --
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 2007 by the American Society for Pharmacology and Experimental Therapeutics