Metabolism of Trichloroethylene in Liver Microsomes

II. Identification of the Reaction Product as Chloral Hydrate

  1. KEITH H. BYINGTON and
  2. KENNETH C. LEIBMAN
  1. Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida

    Abstract

    The product of metabolism of trichloroethylene in rat liver microsomes has been characterized as chloral hydrate. In common with chloral hydrate, the metabolite is converted to dichloroacetic acid upon reaction with basic cyanide; to chloroglyoxal bis-2,4-dinitrophenylhydrazone upon treatment with 2,4-dinitrophenylhydrazine in acid; to trichloroethanol by the action of liver alcohol dehydrogenase; and to trichloroacetic acid upon oxidation mediated by chloral hydrate dehydrogenase. Possible mechanisms of the conversion of trichloroethylene to chloral hydrate are discussed.

    Footnotes

      • Received July 19, 1965.
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    1. Molecular Pharmacology November 1965 vol. 1 no. 3 247-254
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