The correlation among the inhibitory potencies for rat liver ATP:L-methionine S-adenosyltransferase of a series of 11 substituted O-phenyl-DL-homoserines and various Hammett σ and Hansch π coefficients has been examined. Regression analyses by the method of least squares gave the best correlation by the use of a linear combination of ordinary σ values and π values for phenoxyacetic acid derivatives. The analysis gave the linear free energy relationship pI50 = 0.619π + 0.614σ + 1.62 for n = 11. The correlation coefficient of r = 0.989 inidicated that an almost complete correspondence of structural properties with potency was achieved
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