Abstract
The correlation among the inhibitory potencies for rat liver ATP:L-methionine S-adenosyltransferase of a series of 11 substituted O-phenyl-DL-homoserines and various Hammett σ and Hansch π coefficients has been examined. Regression analyses by the method of least squares gave the best correlation by the use of a linear combination of ordinary σ values and π values for phenoxyacetic acid derivatives. The analysis gave the linear free energy relationship pI50 = 0.619π + 0.614σ + 1.62 for n = 11. The correlation coefficient of r = 0.989 inidicated that an almost complete correspondence of structural properties with potency was achieved
- Copyright ©, 1974, by Academic Press, Inc.
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.