A study of the conformation of neuroleptic durgs by X-ray diffraction and simple conformational calculations has revealed some relationships among the relative arrangements of possible pharmacodynamic groups for these substances. A hydrogen bond donor at an appropriate distance from the basic nitrogen common to most neuroleptics often results in an enhancement of activity.
ACKNOWLEDGMENTS I am much indebted to Dr. P. A. J. Janssen and Dr. J. Tollenaere for stimulating discussions. I also thank Professor M. Van Meerssche for his interest in this work.
- Copyright ©, 1974, by Academic Press, Inc.