Abstract
The absorption spectrum of distamycin A was changed by poly dA, poly dT, poly dG, and poly dC and also by ΦX 174 DNA. Poly dA and, to a lesser extent, poly dG induced a Cotton effect in the optical rotatory dispersion spectrum of distamycin A. The complex of distamycin A and ΦX 174 DNA showed a reverisble cooperative transition upon heating and cooling. Distamycin A inhibited the template activities of poly dA and poly dT in an RNA polymerase reaction in vitro.
- Copyright © 1976 by Academic Press, Inc.
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