Abstract
The embryotoxic and teratogenic activities of three thalidomide analogues containing nonplanar tetrahydrophthalimide moieties, of the corresponding three imides, and of their N-methyl derivatives were tested in SWS mice. The molecular structures of three imides were established simultaneously by X-ray diffraction analysis. One of the three nonplanar thalidomide analogues is teratogenic and therefore does not support the intercalation hypothesis of the thalidomide action. The tendency of the three sulfur-containing compounds for complex formation is discussed.
- Copyright © 1977 by Academic Press, Inc.
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