Abstract
Molecular connectivity indices were calculated for 28 inhalation anesthetics. An excellent correlation is obtained between the relative anesthetic potency and the molecular connectivity index 0χ[unknown] in addition to the charge QH on the polar hydrogens. This quantitative structure-activity relationship accounts for and quantifies previous observations on general anesthetics. Our structure-activity relationship is discussed briefly in relation to theories of general anesthesia.
- Copyright © 1977 by Academic Press, Inc.
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