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Molecular Pharmacology

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Research ArticleArticle

Characteristics of the Liver Microsomal Drug-Metabolizing Enzyme System of Newborn Rats

MICHAEL M. IBA, LESTER F. SOYKA and MARTIN P. SCHULMAN
Molecular Pharmacology November 1977, 13 (6) 1092-1104;
MICHAEL M. IBA
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612
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LESTER F. SOYKA
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612
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MARTIN P. SCHULMAN
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612
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Abstract

Sodium dithionite-reduced hepatic microsomes from neonatal (5-7-day-old) rats displayed (a) an absorption maximum at 452 nm in the presence of carbon monoxide and (b) an equilibrium for the ethyl isocyanide-induced absorption peaks at 430 and 455 nm at pH 7.9. These preparations elicited little or no spectral change with ethylmorphine but elicited the type R-I spectral change with other type I substrates. Carbon monoxide formation in the presence of NADPH and the rate of conversion of cytochrome P-450 to cytochrome P-420 by mersalyl (sodium [(3-hydroxymercuri-2-methoxypropyl)-carbamoyl]phenoxyacetate) were greater in microsomes from neonates than in those from adults. In the presence of NADPH, lipid peroxidatic activity was high, ethylmorphine N-demethylation was low, and aniline hydroxylation was the same in microsomes from neonates compared with the same activities in microsomes from adults. In the presence of NADH, ethylmorphine N-demethylase activities in both the adult and neonatal preparations were identical, but more cytochrome P-450 was reducible by this nucleotide in the latter preparation. These observations demonstrate that the drug-metabolizing system of the neonate differs from that of the adult.

  • Copyright © 1977 by Academic Press, Inc.

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Molecular Pharmacology
Vol. 13, Issue 6
1 Nov 1977
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Research ArticleArticle

Characteristics of the Liver Microsomal Drug-Metabolizing Enzyme System of Newborn Rats

MICHAEL M. IBA, LESTER F. SOYKA and MARTIN P. SCHULMAN
Molecular Pharmacology November 1, 1977, 13 (6) 1092-1104;

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Research ArticleArticle

Characteristics of the Liver Microsomal Drug-Metabolizing Enzyme System of Newborn Rats

MICHAEL M. IBA, LESTER F. SOYKA and MARTIN P. SCHULMAN
Molecular Pharmacology November 1, 1977, 13 (6) 1092-1104;
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