1-Naphthylthiourea: A Mutagenic Rodenticide that Transforms Hamster Embryo Cells

  1. J. C. KAWALEK,
  2. A. W. ANDREWS and
  3. R. J. PIENTA
  1. Chemical Carcinogenesis Program, NCI Frederick Cancer Research Center, Frederick, MD 21701

    Abstract

    1-Naphthylthiourea is a rodenticide which produces pulmonary edema. It is mutagenic when metabolized by liver microsomal fractions from rats treated with either Aroclor 1254 or phenobarbital. It also transforms hamster embryo cells in an in vitro carcinogenesis bioassay.

    Footnotes

      • Received August 18, 1978.
      • Accepted December 11, 1978.
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    1. Molecular Pharmacology May 1979 vol. 15 no. 3 678-684
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