Abstract
Metronidazole is reduced by a variety of electron donors in an in vitro system containing milk xanthine oxidase. With hypoxanthine as electron donor, the products and their yields are as follows: N-(2-hydroxyethyl)-oxamic acid, 2.2%; N-glycoylethanolamine, 2.7%; N-acetylethanolamine, 2.4%; ethanolamine, 15.3%; acetate, 4.8%; acetamide, 14.1%; and glycine, 8%. Additional glycine is found when the reaction products are hydrolyzed. These products are consistent with a number of patterns of fragmentation of the imidazole ring which suggest the existence of several labile intermediates in the reduction of metronidazole.
- Copyright © 1980 by The American Society for Pharmacology and Experimental Therapeutics
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