Dopamine- and Serotonin-Sensitive Adenylate Cyclase in the Gill of Aplysia californica

  1. SAM WEISS and
  2. GEORGE I. DRUMMOND
  1. University Biochemistry Group, Division of Biochemistry, Department of Chemistry, University of Calgary, Calgary T2N 1N4 Canada

    Abstract

    Stimulation of adenylate cyclase by dopamine and serotonin was examined in a particulate fraction of Aplysia gill homogenates. Dopamine augmented activity 3- to 5-fold (EC50, 10µ M), whereas serotonin increased activity 15- to 20-fold (EC50, 1 µM). Lysergic acid diethylamide and several ergot alkaloids were full or partial agonists for enzyme stimulation. Structure-activity relationships of dopaminergic and serotonergic stimulation and the blocking action of several antagonists suggest that structural similarities exist between the receptors that mediate dopamine and serotonin stimulation of adenylate cyclase.

    Footnotes

      • Received May 7, 1981.
      • Accepted July 27, 1981.
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    1. Molecular Pharmacology November 1981 vol. 20 no. 3 592-597
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