Abstract
3'-Amino-3'-deoxyadenosine strongly inhibits nucleic acid labeling in Ehrlich ascites tumor cells. The compound is shown to be converted to corresponding 5'-phosphates in the cells. 3'-Amino-3'-deoxy-ATP blocks RNA formation as catalyzed by the aggregate enzyme and by isolated nuclei. It is suggested that growing RNA chains incorporate the 3'-amino-3'-deoxyadenosine 5'-phosphate into their free 3'-OH end groups, and are thereafter unable to support further synthesis.
ACKNOWLEDGMENT This work was supported in part by a grant from Carlsberg-fondet of Copenhagen, Denmark, and was done while J. Truman was a Fellow of the Medical Foundation, Inc., of Boston, Massachusetts.
- Copyright ©, 1968, by Academic Press Inc.
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