Table of Contents

Articles

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  Metabolic Effects of Rexinoids: Tissue-Specific Regulation of Lipoprotein Lipase Activity

  Peter J. A. Davies, Stacey A. Berry, Gregory L. Shipley, Robert H. Eckel, Nathalie Hennuyer, Diane L. Crombie, Kathleen M. Ogilvie, Julia Peinado-Onsurbe, Catherine Fievet, Mark D. Leibowitz, Richard A. Heyman and Johan Auwerx

  Molecular Pharmacology February 2001, 59 (2) 170-176; DOI: https://doi.org/10.1124/mol.59.2.170
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  Regulation of Human β-Glucuronidase by A23187 and Thapsigargin in the Hepatoma Cell Line HepG2

  Bernhard Sperker, Céline Tomkiewicz, Oliver Burk, Robert Barouki and Heyo K. Kroemer

  Molecular Pharmacology February 2001, 59 (2) 177-182; DOI: https://doi.org/10.1124/mol.59.2.177
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  Irreversible Block of Human Heart (hH1) Sodium Channels by the Plant Alkaloid Lappaconitine

  Sterling N. Wright

  Molecular Pharmacology February 2001, 59 (2) 183-192; DOI: https://doi.org/10.1124/mol.59.2.183
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  Nitrogen-Bisphosphonates Block Retinoblastoma Phosphorylation and Cell Growth by Inhibiting the Cholesterol Biosynthetic Pathway in a Keratinocyte Model for Esophageal Irritation

  Alfred A. Reszka, Judit Halasy-Nagy and Gideon A. Rodan

  Molecular Pharmacology February 2001, 59 (2) 193-202; DOI: https://doi.org/10.1124/mol.59.2.193
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  Role of an Inverted CCAAT Element in Human Topoisomerase IIα Gene Expression in ICRF-187-Sensitive and -Resistant CEM Leukemic Cells

  Susan E. Morgan and William T. Beck

  Molecular Pharmacology February 2001, 59 (2) 203-211; DOI: https://doi.org/10.1124/mol.59.2.203
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  Changes in Agonist Concentration Dependence That Are a Function of Duration of Exposure SuggestN-Methyl-d-aspartate Receptor Nonsaturation during Synaptic Stimulation

  Nansheng Chen, Jihong Ren, Lynn A. Raymond and Timothy H. Murphy

  Molecular Pharmacology February 2001, 59 (2) 212-219; DOI: https://doi.org/10.1124/mol.59.2.212
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  Molecular Mechanisms Involved in the Synergistic Activation of Soluble Guanylyl Cyclase by YC-1 and Nitric Oxide in Endothelial Cells

  Kurt Schmidt, Astrid Schrammel, Doris Koesling and Bernd Mayer

  Molecular Pharmacology February 2001, 59 (2) 220-224; DOI: https://doi.org/10.1124/mol.59.2.220
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  Pharmacological Comparison of Native Mitochondrial K_ATP Channels with Molecularly Defined Surface K_ATP Channels

  Yongge Liu, Guifen Ren, Brian O'Rourke, Eduardo Marbán and Jegatheesan Seharaseyon

  Molecular Pharmacology February 2001, 59 (2) 225-230; DOI: https://doi.org/10.1124/mol.59.2.225
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  Spermine Deficiency Resulting from Targeted Disruption of the Spermine Synthase Gene in Embryonic Stem Cells Leads to Enhanced Sensitivity to Antiproliferative Drugs

  Veli-Pekka Korhonen, Kirsi Niiranen, Maria Halmekytö, Marko Pietilä, Paula Diegelman, Jyrki J. Parkkinen, Terho Eloranta, Carl W. Porter, Leena Alhonen and Juhani Jänne

  Molecular Pharmacology February 2001, 59 (2) 231-238; DOI: https://doi.org/10.1124/mol.59.2.231
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  β-Arrestin- and Dynamin-Dependent Endocytosis of the AT₁ Angiotensin Receptor

  Zsuzsanna Gáborik, Márta Szaszák, László Szidonya, Borbála Balla, Sándor Paku, Kevin J. Catt, Adrian J. L. Clark and László Hunyady

  Molecular Pharmacology February 2001, 59 (2) 239-247; DOI: https://doi.org/10.1124/mol.59.2.239
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  Paclitaxel-Induced Immune Suppression Is Associated with NF-κB Activation Via Conventional PKC Isotypes in Lipopolysaccharide-Stimulated 70Z/3 Pre-B Lymphocyte Tumor Cells

  Michael Lee and Young Jin Jeon

  Molecular Pharmacology February 2001, 59 (2) 248-253; DOI: https://doi.org/10.1124/mol.59.2.248
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  Involvement of Asp-Glu-Val-Asp-Directed, Caspase-Mediated Mitogen-Activated Protein Kinase Kinase 1 Cleavage, c-Jun N-Terminal Kinase Activation, and Subsequent Bcl-2 Phosphorylation for Paclitaxel-Induced Apoptosis in HL-60 Cells

  Shine-Gwo Shiah, Shuang-En Chuang and Min-Liang Kuo

  Molecular Pharmacology February 2001, 59 (2) 254-262; DOI: https://doi.org/10.1124/mol.59.2.254
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  Rapid Polyubiquitination and Proteasomal Degradation of a Mutant Form of NAD(P)H:Quinone Oxidoreductase 1

  David Siegel, Adil Anwar, Shannon L. Winski, Jadwiga K. Kepa, Kathryn L. Zolman and David Ross

  Molecular Pharmacology February 2001, 59 (2) 263-268; DOI: https://doi.org/10.1124/mol.59.2.263
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  Inhibition of Human Ether-A-Go-Go Potassium Channels by Cocaine

  Michael E. O'Leary

  Molecular Pharmacology February 2001, 59 (2) 269-277; DOI: https://doi.org/10.1124/mol.59.2.269
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  Nuclear Receptor CAR as a Regulatory Factor for the Sexually Dimorphic Induction of CYP2B1 Gene by Phenobarbital in Rat Livers

  Kouichi Yoshinari, Tatsuya Sueyoshi, Rick Moore and Masahiko Negishi

  Molecular Pharmacology February 2001, 59 (2) 278-284; DOI: https://doi.org/10.1124/mol.59.2.278
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  Mutation of Gln125 to Asn Selectively Abolishes the Thymidylate Kinase Activity of Herpes Simplex Virus Type 1 Thymidine Kinase

  Bart Degrève, Robert Esnouf, Erik De Clercq and Jan Balzarini

  Molecular Pharmacology February 2001, 59 (2) 285-293; DOI: https://doi.org/10.1124/mol.59.2.285
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  Local Anesthetic Inhibition of G Protein-Coupled Receptor Signaling by Interference with Gα_q Protein Function

  Markus W. Hollmann, Kathrin S. Wieczorek, Andreas Berger and Marcel E. Durieux

  Molecular Pharmacology February 2001, 59 (2) 294-301; DOI: https://doi.org/10.1124/mol.59.2.294
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  The Role of NF-κB as a Survival Factor in Environmental Chemical-Induced Pre-B Cell Apoptosis

  Koren K. Mann, Stefan Doerre, Jennifer J. Schlezinger, David H. Sherr and Shafat Quadri

  Molecular Pharmacology February 2001, 59 (2) 302-309; DOI: https://doi.org/10.1124/mol.59.2.302
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  The Role of Phosphorylation/Dephosphorylation in Agonist-Induced Desensitization of D₁ Dopamine Receptor Function: Evidence for a Novel Pathway for Receptor Dephosphorylation

  Ben Gardner, Zhi Fang Liu, Dong Jiang and David R. Sibley

  Molecular Pharmacology February 2001, 59 (2) 310-321; DOI: https://doi.org/10.1124/mol.59.2.310
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  The Sulfonylurea Glimepiride Regulates Intracellular Routing of the Insulin-Receptor Complexes through Their Interaction with Specific Protein Kinase C Isoforms

  Marta Letizia Hribal, Rossella D'Alfonso, Barbara Giovannone, Davide Lauro, Yong Yu Liu, Patrizia Borboni, Massimo Federici, Renato Lauro and Giorgio Sesti

  Molecular Pharmacology February 2001, 59 (2) 322-330; DOI: https://doi.org/10.1124/mol.59.2.322
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  Partial Agonist Clonidine Mediates α₂-AR Subtypes Specific Regulation of cAMP Accumulation in Adenylyl Cyclase II Transfected DDT1-MF2 Cells

  Isabelle Limon-Boulez, Rachel Bouet-Alard, Tom W. Gettys, Stephen M. Lanier, Jean-Paul Maltier and Chantal Legrand

  Molecular Pharmacology February 2001, 59 (2) 331-338; DOI: https://doi.org/10.1124/mol.59.2.331
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  A Novel Proton-Dependent Nucleoside Transporter, CeCNT3, fromCaenorhabditis elegans

  Guangqing Xiao, Juan Wang, Tonje Tangen and Kathleen M. Giacomini

  Molecular Pharmacology February 2001, 59 (2) 339-348; DOI: https://doi.org/10.1124/mol.59.2.339
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  Characterization of a G Protein-Coupled Receptor for Nicotinic Acid

  Anna Lorenzen, Christina Stannek, Heidrun Lang, Viktor Andrianov, Ivars Kalvinsh and Ulrich Schwabe

  Molecular Pharmacology February 2001, 59 (2) 349-357; DOI: https://doi.org/10.1124/mol.59.2.349
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  Molecular and Physiological Evidence for Multifunctionality of Carnitine/Organic Cation Transporter OCTN2

  Rikiya Ohashi, Ikumi Tamai, Jun-ichi Nezu, Hiroko Nikaido, Noriyoshi Hashimoto, Asuka Oku, Yoshimichi Sai, Miyuki Shimane and Akira Tsuji

  Molecular Pharmacology February 2001, 59 (2) 358-366; DOI: https://doi.org/10.1124/mol.59.2.358
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  A Novel Protein Complex Distinct from Mismatch Repair Binds Thioguanylated DNA

  Eugene Y. Krynetski, Natalia F. Krynetskaia, Amy E. Gallo, K. Gopal Murti and William E. Evans

  Molecular Pharmacology February 2001, 59 (2) 367-374; DOI: https://doi.org/10.1124/mol.59.2.367
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  Analysis of the C-Terminal Tail of the Rat Thyrotropin-Releasing Hormone Receptor-1 in Interactions and Cointernalization with β-Arrestin 1-Green Fluorescent Protein

  D. Alex Groarke, Tomas Drmota, Daljit S. Bahia, Nicholas A. Evans, Shelagh Wilson and Graeme Milligan

  Molecular Pharmacology February 2001, 59 (2) 375-385; DOI: https://doi.org/10.1124/mol.59.2.375
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  cDNA Cloning and Initial Characterization of CYP3A43, a Novel Human Cytochrome P450

  Tammy L. Domanski, Csaba Finta, James R. Halpert and Peter G. Zaphiropoulos

  Molecular Pharmacology February 2001, 59 (2) 386-392; DOI: https://doi.org/10.1124/mol.59.2.386
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  Molecular Mechanisms Controlling the Rate and Specificity of Catechol O-Methylation by Human Soluble Catechol O-Methyltransferase

  Pia Lautala, Ismo Ulmanen and Jyrki Taskinen

  Molecular Pharmacology February 2001, 59 (2) 393-402; DOI: https://doi.org/10.1124/mol.59.2.393