An Orphan Receptor Adopted by a Family of Transmitters
- Department of Pharmacology and Developmental and Cell Biology, University of California, Irvine, Irvine, California
- Address correspondence to:
Olivier Civelli, Department of Pharmacology, University of California, Irvine, Med Surge II, Room 369, Irvine, CA 92697-4625. E-mail: ocivelli{at}uci.edu
Abstract
A tenet of pharmacology states that a receptor must be selective for and bind its natural ligand with high affinity. Recently discovered ligands of some deorphanized G protein-coupled receptors challenge this concept.
Footnotes
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Article, publication date, and citation information can be found at http://molpharm.aspetjournals.org.
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doi:10.1124/mol.104.010348.
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Please see the related article on page 589.
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ABBREVIATION: GPCR, G protein-coupled receptor.
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- Received December 15, 2004.
- Accepted December 16, 2004.
- The American Society for Pharmacology and Experimental Therapeutics
