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Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Receptor

Oliver Burk, Katja A. Arnold, Andreas K. Nussler, Elke Schaeffeler, Ekaterina Efimova, Bonnie A. Avery, Mitchell A. Avery, Martin F. Fromm and Michel Eichelbaum
Molecular Pharmacology June 2005, 67 (6) 1954-1965; DOI: https://doi.org/10.1124/mol.104.009019

Article Information

vol. 67 no. 6 1954-1965
DOI 
https://doi.org/10.1124/mol.104.009019
PubMed 
15761118
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received November 9, 2004
  • Accepted March 10, 2005
  • Published online May 16, 2005.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Oliver Burk,
  2. Katja A. Arnold,
  3. Andreas K. Nussler,
  4. Elke Schaeffeler,
  5. Ekaterina Efimova,
  6. Bonnie A. Avery,
  7. Mitchell A. Avery,
  8. Martin F. Fromm and
  9. Michel Eichelbaum
  1. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (O.B., K.A.A., E.S., M.F.F., M.E.); Department of Surgery, Charité, Campus-Virchow-Clinic, Humboldt University, Berlin, Germany (A.K.N., E.E.); Departments of Pharmaceutics and Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, Mississippi (B.A.A., M.A.A.); and Institute of Clinical and Experimental Pharmacology and Toxicology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany (M.F.F.)
  1. Address correspondence to:
    Dr. Oliver Burk, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany. E-mail: oliver.burk{at}ikp-stuttgart.de
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Research ArticleArticle

Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Receptor

Oliver Burk, Katja A. Arnold, Andreas K. Nussler, Elke Schaeffeler, Ekaterina Efimova, Bonnie A. Avery, Mitchell A. Avery, Martin F. Fromm and Michel Eichelbaum
Molecular Pharmacology June 1, 2005, 67 (6) 1954-1965; DOI: https://doi.org/10.1124/mol.104.009019
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