Abstract
The contribution by Micheva et al. (p. 467) in this issue of Molecular Pharmacology adds to our understanding of the action of pregabalin, a drug used for treatment of partial seizures and neuropathic pain. The authors examine the effects of pregabalin on presynaptic function of cultured hippocampal neurons using a powerful technique to follow the trafficking of synaptic vesicles in individual boutons. The study revealed that pregabalin reduces the readily releasable pool of synaptic vesicles in an N-methyl-d-aspartate receptor-dependent manner.
- Received May 22, 2006.
- Accepted May 25, 2006.
- The American Society for Pharmacology and Experimental Therapeutics
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