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Research ArticleArticle

Dexamethasone-Mediated Up-Regulation of Human CYP2A6 Involves the Glucocorticoid Receptor and Increased Binding of Hepatic Nuclear Factor 4α to the Proximal Promoter

Tania Onica, Kathleen Nichols, Meghan Larin, Lorraine Ng, Ann Maslen, Zdenek Dvorak, Jean-Marc Pascussi, Marie-Josée Vilarem, Patrick Maurel and Gordon M. Kirby
Molecular Pharmacology February 2008, 73 (2) 451-460; DOI: https://doi.org/10.1124/mol.107.039354
Tania Onica
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Kathleen Nichols
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Meghan Larin
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Lorraine Ng
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Ann Maslen
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Zdenek Dvorak
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Jean-Marc Pascussi
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Marie-Josée Vilarem
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Patrick Maurel
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Gordon M. Kirby
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Article Information

vol. 73 no. 2 451-460
DOI 
https://doi.org/10.1124/mol.107.039354
PubMed 
17978169

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 12, 2007
  • Accepted October 31, 2007
  • Published online January 23, 2008.

Article Versions

  • Earlier version (October 31, 2007 - 11:17).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tania Onica,
  2. Kathleen Nichols,
  3. Meghan Larin,
  4. Lorraine Ng,
  5. Ann Maslen,
  6. Zdenek Dvorak,
  7. Jean-Marc Pascussi,
  8. Marie-Josée Vilarem,
  9. Patrick Maurel and
  10. Gordon M. Kirby
  1. Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada (T.O., K.N., M.L., L.N., A.M., G.M.K.); Institut National de la Santé et de la Recherche Médicale U632, Montpellier, France, and Univ Montpellier1, Montpellier, France (J.-M.P., M.-J.V., P.M.); and Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Olomouc, Czech Republic (Z.D.)
  1. Address correspondence to:
    Dr. Gordon M. Kirby, Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1. E-mail: gkirby{at}uoguelph.ca
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Molecular Pharmacology: 73 (2)
Molecular Pharmacology
Vol. 73, Issue 2
1 Feb 2008
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Research ArticleArticle

Dexamethasone-Mediated Up-Regulation of Human CYP2A6 Involves the Glucocorticoid Receptor and Increased Binding of Hepatic Nuclear Factor 4α to the Proximal Promoter

Tania Onica, Kathleen Nichols, Meghan Larin, Lorraine Ng, Ann Maslen, Zdenek Dvorak, Jean-Marc Pascussi, Marie-Josée Vilarem, Patrick Maurel and Gordon M. Kirby
Molecular Pharmacology February 1, 2008, 73 (2) 451-460; DOI: https://doi.org/10.1124/mol.107.039354

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Research ArticleArticle

Dexamethasone-Mediated Up-Regulation of Human CYP2A6 Involves the Glucocorticoid Receptor and Increased Binding of Hepatic Nuclear Factor 4α to the Proximal Promoter

Tania Onica, Kathleen Nichols, Meghan Larin, Lorraine Ng, Ann Maslen, Zdenek Dvorak, Jean-Marc Pascussi, Marie-Josée Vilarem, Patrick Maurel and Gordon M. Kirby
Molecular Pharmacology February 1, 2008, 73 (2) 451-460; DOI: https://doi.org/10.1124/mol.107.039354
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