Research ArticleArticle
Discovery of a Quorum-Sensing Inhibitor of Drug-Resistant Staphylococcal Infections by Structure-Based Virtual Screening
Madanahally D. Kiran, Nallini Vijayarangan Adikesavan, Oscar Cirioni, Andrea Giacometti, Carmela Silvestri, Giorgio Scalise, Roberto Ghiselli, Vittorio Saba, Fiorenza Orlando, Menachem Shoham and Naomi Balaban
Molecular Pharmacology May 2008, 73 (5) 1578-1586; DOI: https://doi.org/10.1124/mol.107.044164
Madanahally D. Kiran
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Nallini Vijayarangan Adikesavan
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Oscar Cirioni
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Andrea Giacometti
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Carmela Silvestri
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Giorgio Scalise
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Roberto Ghiselli
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Vittorio Saba
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Fiorenza Orlando
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Menachem Shoham
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
Naomi Balaban
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (M.D.K., N.B.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (N.V.A., M.S.); Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy (O.C., A.G., C.S., G.S.); Department of General Surgery, Instituto Nazionale Riposo e Cura Anziani/Instituto de Ricovero e Cura a Carattere Scientifico (INRCA IRRCS), University of Ancona, Ancona, Italy (R.G., V.S.); and Experimental Animal Models for Aging Units, Research Department, INRCA IRRCS, Ancona, Italy (F.O.)
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Research ArticleArticle
Discovery of a Quorum-Sensing Inhibitor of Drug-Resistant Staphylococcal Infections by Structure-Based Virtual Screening
Madanahally D. Kiran, Nallini Vijayarangan Adikesavan, Oscar Cirioni, Andrea Giacometti, Carmela Silvestri, Giorgio Scalise, Roberto Ghiselli, Vittorio Saba, Fiorenza Orlando, Menachem Shoham and Naomi Balaban
Molecular Pharmacology May 1, 2008, 73 (5) 1578-1586; DOI: https://doi.org/10.1124/mol.107.044164
Research ArticleArticle
Discovery of a Quorum-Sensing Inhibitor of Drug-Resistant Staphylococcal Infections by Structure-Based Virtual Screening
Madanahally D. Kiran, Nallini Vijayarangan Adikesavan, Oscar Cirioni, Andrea Giacometti, Carmela Silvestri, Giorgio Scalise, Roberto Ghiselli, Vittorio Saba, Fiorenza Orlando, Menachem Shoham and Naomi Balaban
Molecular Pharmacology May 1, 2008, 73 (5) 1578-1586; DOI: https://doi.org/10.1124/mol.107.044164
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