Table of Contents

April 2009; 75 (4)

MINIREVIEW

    • Pierre-Alexandre Vidi and
    • Val J. Watts

    Fluorescent and Bioluminescent Protein-Fragment Complementation Assays in the Study of G Protein-Coupled Receptor Oligomerization and Signaling

    Mol Pharmacol April 2009 75:733-739; published ahead of print January 13, 2009, doi:10.1124/mol.108.053819

Perspective

    • William L. Holland and
    • Philipp E. Scherer

    PAQRs: A Counteracting Force to Ceramides?

    Mol Pharmacol April 2009 75:740-743; doi:10.1124/mol.109.054817

Accelerated Communication

    • Qifang Wu,
    • Lei Zhang,
    • Ping-Yee Law,
    • Li-Na Wei,
    • and Horace H. Loh

    Long-Term Morphine Treatment Decreases the Association of μ-Opioid Receptor (MOR1) mRNA with Polysomes through miRNA23b

    Mol Pharmacol April 2009 75:744-750; published ahead of print January 14, 2009, doi:10.1124/mol.108.053462

Articles

    • Matthew T. Duvernay,
    • Chunmin Dong,
    • Xiaoping Zhang,
    • Fuguo Zhou,
    • Charles D. Nichols,
    • and Guangyu Wu

    Anterograde Trafficking of G Protein-Coupled Receptors: Function of the C-Terminal F(X)6LL Motif in Export from the Endoplasmic Reticulum

    Mol Pharmacol April 2009 75:751-761; published ahead of print December 31, 2008, doi:10.1124/mol.108.051623
    • M. W. Pennington,
    • C. Beeton,
    • C. A. Galea,
    • B. J. Smith,
    • V. Chi,
    • K. P. Monaghan,
    • A. Garcia,
    • S. Rangaraju,
    • A. Giuffrida,
    • D. Plank,
    • G. Crossley,
    • D. Nugent,
    • I. Khaytin,
    • Y. LeFievre,
    • I. Peshenko,
    • C. Dixon,
    • S. Chauhan,
    • A. Orzel,
    • T. Inoue,
    • X. Hu,
    • R. V. Moore,
    • R. S. Norton,
    • and K. G. Chandy

    Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

    Mol Pharmacol April 2009 75:762-773; doi:10.1124/mol.108.052704
    • Dong I. Lee,
    • Michael G. Klein,
    • Weizhong Zhu,
    • Rui-Ping Xiao,
    • Volodymyr Gerzanich,
    • and Kai Y. Xu

    Activation of (Na++K+)-ATPase Modulates Cardiac L-Type Ca2+ Channel Function

    Mol Pharmacol April 2009 75:774-781; published ahead of print January 2, 2009, doi:10.1124/mol.108.052597
    • Takero Nakajima,
    • Naoki Tanaka,
    • Hiroki Kanbe,
    • Atsushi Hara,
    • Yuji Kamijo,
    • Xiaowei Zhang,
    • Frank J. Gonzalez,
    • and Toshifumi Aoyama

    Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor α-Independent Mechanism

    Mol Pharmacol April 2009 75:782-792; published ahead of print January 5, 2009, doi:10.1124/mol.108.052928
    • Kostas Gkountelias,
    • Theodoros Tselios,
    • Maria Venihaki,
    • George Deraos,
    • Iakovos Lazaridis,
    • Olga Rassouli,
    • Achille Gravanis,
    • and George Liapakis

    Alanine Scanning Mutagenesis of the Second Extracellular Loop of Type 1 Corticotropin-Releasing Factor Receptor Revealed Residues Critical for Peptide Binding

    Mol Pharmacol April 2009 75:793-800; published ahead of print January 5, 2009, doi:10.1124/mol.108.052423
    • Martina Alken,
    • Antje Schmidt,
    • Claudia Rutz,
    • Jens Furkert,
    • Gunnar Kleinau,
    • Walter Rosenthal,
    • and Ralf Schülein

    The Sequence after the Signal Peptide of the G Protein-Coupled Endothelin B Receptor Is Required for Efficient Translocon Gating at the Endoplasmic Reticulum Membrane

    Mol Pharmacol April 2009 75:801-811; published ahead of print January 9, 2009, doi:10.1124/mol.108.051581
    • Wenbo Zhu,
    • Yanqiu Ou,
    • Yan Li,
    • Ru Xiao,
    • Minfeng Shu,
    • Yuehan Zhou,
    • Jun Xie,
    • Songmin He,
    • Pengxin Qiu,
    • and Guangmei Yan

    A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma Cells via Down-Regulation of the Nuclear Factor-κB Pathway

    Mol Pharmacol April 2009 75:812-819; published ahead of print January 21, 2009, doi:10.1124/mol.108.052605
    • Thomas E. Taylor-Clark,
    • Srinivas Ghatta,
    • Weston Bettner,
    • and Bradley J. Undem

    Nitrooleic Acid, an Endogenous Product of Nitrative Stress, Activates Nociceptive Sensory Nerves via the Direct Activation of TRPA1

    Mol Pharmacol April 2009 75:820-829; doi:10.1124/mol.108.054445
    • Agnes C. L. Martin,
    • Debbie Willoughby,
    • Antonio Ciruela,
    • Laura-Jo Ayling,
    • Mario Pagano,
    • Sebastian Wachten,
    • Anders Tengholm,
    • and Dermot M. F. Cooper

    Capacitative Ca2+ Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8

    Mol Pharmacol April 2009 75:830-842; doi:10.1124/mol.108.051748
    • Christopher H. So,
    • Vaneeta Verma,
    • Mohammad Alijaniaram,
    • Regina Cheng,
    • Asim J. Rashid,
    • Brian F. O'Dowd,
    • and Susan R. George

    Calcium Signaling by Dopamine D5 Receptor and D5-D2 Receptor Hetero-Oligomers Occurs by a Mechanism Distinct from That for Dopamine D1-D2 Receptor Hetero-Oligomers

    Mol Pharmacol April 2009 75:843-854; published ahead of print January 26, 2009, doi:10.1124/mol.108.051805
    • Lalida Rojanathammanee,
    • Erin B. Harmon,
    • Laurel A. Grisanti,
    • Piyarat Govitrapong,
    • Manuchair Ebadi,
    • Bryon D. Grove,
    • Masaru Miyagi,
    • and James E. Porter

    The 27-kDa Heat Shock Protein Confers Cytoprotective Effects through a β2-Adrenergic Receptor Agonist-Initiated Complex with β-Arrestin

    Mol Pharmacol April 2009 75:855-865; published ahead of print January 27, 2009, doi:10.1124/mol.108.053397
    • Nancy Y. Villa,
    • Brian R. Kupchak,
    • Ibon Garitaonandia,
    • Jessica L. Smith,
    • Emilio Alonso,
    • Charlene Alford,
    • L. Ashley Cowart,
    • Yusuf A. Hannun,
    • and Thomas J. Lyons

    Sphingolipids Function as Downstream Effectors of a Fungal PAQR

    Mol Pharmacol April 2009 75:866-875; published ahead of print December 9, 2008, doi:10.1124/mol.108.049809
    • Koen van de Wetering,
    • Alexander Burkon,
    • Wouter Feddema,
    • Alice Bot,
    • Hugo de Jonge,
    • Veronika Somoza,
    • and Piet Borst

    Intestinal Breast Cancer Resistance Protein (BCRP)/Bcrp1 and Multidrug Resistance Protein 3 (MRP3)/Mrp3 Are Involved in the Pharmacokinetics of Resveratrol

    Mol Pharmacol April 2009 75:876-885; published ahead of print December 29, 2008, doi:10.1124/mol.108.052019
    • Bernd Mayer,
    • Andrei L. Kleschyov,
    • Heike Stessel,
    • Michael Russwurm,
    • Thomas Münzel,
    • Doris Koesling,
    • and Kurt Schmidt

    Inactivation of Soluble Guanylate Cyclase by Stoichiometric S-Nitrosation

    Mol Pharmacol April 2009 75:886-891; published ahead of print December 29, 2008, doi:10.1124/mol.108.052142
    • Alan M. Roloff and
    • Stanley A. Thayer

    Modulation of Excitatory Synaptic Transmission by Δ9-Tetrahydrocannabinol Switches from Agonist to Antagonist Depending on Firing Rate

    Mol Pharmacol April 2009 75:892-900; published ahead of print December 31, 2008, doi:10.1124/mol.108.051482
    • Shu-Chen Lu,
    • Jing Xu,
    • Narumol Chinookoswong,
    • Shuying Liu,
    • Shirley Steavenson,
    • Colin Gegg,
    • David Brankow,
    • Richard Lindberg,
    • Murielle Véniant,
    • and Wei Gu

    An Acyl-Ghrelin-Specific Neutralizing Antibody Inhibits the Acute Ghrelin-Mediated Orexigenic Effects in Mice

    Mol Pharmacol April 2009 75:901-907; published ahead of print January 7, 2009, doi:10.1124/mol.108.052852
    • Tarek Z. Deeb,
    • Douglas Sharp,
    • and Tim G. Hales

    Direct Subunit-Dependent Multimodal 5-Hydroxytryptamine3 Receptor Antagonism by Methadone

    Mol Pharmacol April 2009 75:908-917; published ahead of print January 8, 2009, doi:10.1124/mol.108.053322
    • Tristan D. McClure-Begley,
    • Nathan M. King,
    • Allan C. Collins,
    • Jerry A. Stitzel,
    • Jeanne M. Wehner,
    • and Christopher M. Butt

    Acetylcholine-Stimulated [3H]GABA Release from Mouse Brain Synaptosomes is Modulated by α4β2 and α4α5β2 Nicotinic Receptor Subtypes

    Mol Pharmacol April 2009 75:918-926; published ahead of print January 12, 2009, doi:10.1124/mol.108.052274
    • Lu Wang,
    • Adrienne T. Dennis,
    • Phan Trieu,
    • Francois Charron,
    • Natalie Ethier,
    • Terence E. Hebert,
    • Xiaoping Wan,
    • and Eckhard Ficker

    Intracellular Potassium Stabilizes Human Ether-à-go-go-Related Gene Channels for Export from Endoplasmic Reticulum

    Mol Pharmacol April 2009 75:927-937; doi:10.1124/mol.108.053793
    • Xiomara A. Perez,
    • Kathryn T. O'Leary,
    • Neeraja Parameswaran,
    • J. Michael McIntosh,
    • and Maryka Quik

    Prominent Role of α3/α6β2* nAChRs in Regulating Evoked Dopamine Release in Primate Putamen: Effect of Long-Term Nicotine Treatment

    Mol Pharmacol April 2009 75:938-946; published ahead of print January 14, 2009, doi:10.1124/mol.108.053801
    • Jordi Carreras Puigvert,
    • Stephan Huveneers,
    • Lisa Fredriksson,
    • Marieke op het Veld,
    • Bob van de Water,
    • and Erik H. J. Danen

    Cross-Talk between Integrins and Oncogenes Modulates Chemosensitivity

    Mol Pharmacol April 2009 75:947-955; doi:10.1124/mol.108.051649
    • Shuso Takeda,
    • Yuji Ishii,
    • Megumi Iwanaga,
    • Arief Nurrochmad,
    • Yuji Ito,
    • Peter I. Mackenzie,
    • Kiyoshi Nagata,
    • Yasushi Yamazoe,
    • Kazuta Oguri,
    • and Hideyuki Yamada

    Interaction of Cytochrome P450 3A4 and UDP-Glucuronosyltransferase 2B7: Evidence for Protein-Protein Association and Possible Involvement of CYP3A4 J-Helix in the Interaction

    Mol Pharmacol April 2009 75:956-964; published ahead of print January 21, 2009, doi:10.1124/mol.108.052001
    • Natasha T. Snider,
    • James A. Nast,
    • Laura A. Tesmer,
    • and Paul F. Hollenberg

    A Cytochrome P450-Derived Epoxygenated Metabolite of Anandamide Is a Potent Cannabinoid Receptor 2-Selective Agonist

    Mol Pharmacol April 2009 75:965-972; published ahead of print January 26, 2009, doi:10.1124/mol.108.053439
    • John R. Bracamontes and
    • Joe Henry Steinbach

    Steroid Interaction with a Single Potentiating Site Is Sufficient to Modulate GABA-A Receptor Function

    Mol Pharmacol April 2009 75:973-981; doi:10.1124/mol.108.053629
    • Lucie P. Pellissier,
    • Jessica Sallander,
    • Mercedes Campillo,
    • Florence Gaven,
    • Emilie Queffeulou,
    • Marion Pillot,
    • Aline Dumuis,
    • Sylvie Claeysen,
    • Joël Bockaert,
    • and Leonardo Pardo

    Conformational Toggle Switches Implicated in Basal Constitutive and Agonist-Induced Activated States of 5-Hydroxytryptamine-4 Receptors

    Mol Pharmacol April 2009 75:982-990; published ahead of print January 23, 2009, doi:10.1124/mol.108.053686
    • L. Iacovelli,
    • G. Molinaro,
    • G. Battaglia,
    • M. Motolese,
    • L. Di Menna,
    • M. Alfiero,
    • J. Blahos,
    • F. Matrisciano,
    • M. Corsi,
    • C. Corti,
    • V. Bruno,
    • A. De Blasi,
    • and F. Nicoletti

    Regulation of Group II Metabotropic Glutamate Receptors by G Protein-Coupled Receptor Kinases: mGlu2 Receptors Are Resistant to Homologous Desensitization

    Mol Pharmacol April 2009 75:991-1003; doi:10.1124/mol.108.052316

Cover image

Cover image expansion

About the cover: Combination of PCA and RET techniques. See the article by Vidi and Watts on page 733 of this issue.

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April 2009; 75 (4)
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  1. MINIREVIEW
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  3. Accelerated Communication
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