Abstract
We have confirmed that colchicine (1 mM) or vinblastine (100 µM) inhibits the acetylcholine-induced release of catecholamines from perfused bovine adrenal glands. This is an anticholinergic effect of these drugs and cannot be interpreted as evidence that microtubules participate in the release of amines, because neither colchicine nor vinblastine reduced catecholamine released by a high concentration of K+ or by angiotensin. Furthermore, both colchicine (1 mM) and vinblastine (100 µM) blocked transmission through the superior cervical ganglion of the cat by a postsynaptic anti-acetylcholine action.
- Copyright ©, 1972, by Academic Press, Inc.
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