Abstract
Homogeneous cytotoxins I and II with high cytotoxicity to Yoshida sarcoma and hepatoma cells were isolated from the venom of the Indian cobra Naja naja. The amino acid sequence of cytotoxin II was determined with the aid of tryptic digestion and cleavage by cyanogen bromide. Although their pharmacological actions are quite different, the amino acid sequences of cytotoxins were similar to those of cobra neurotoxins.
ACKNOWLEDGMENTS The authors are indebted to Dr. B. Witkop of the National Institutes of Health, United States Public Health Service, for his help in preparing this manuscript , and also to Professor I. Yamashina of our laboratory for valuable discussions and encouragement in the course of the study.
- Copyright ©, 1972, by Academic Press, Inc.
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