Rapid CommunicationMinireview
Writing and Rewriting the Epigenetic Code of Cancer Cells: From Engineered Proteins to Small Molecules
Pilar Blancafort, Jian Jin and Stephen Frye
Molecular Pharmacology March 2013, 83 (3) 563-576; DOI: https://doi.org/10.1124/mol.112.080697
Pilar Blancafort
School of Anatomy, Physiology, and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia (P.B.); and Division Chemical Biology and Medicinal Chemistry, and Center for Integrative Chemical Biology and Drug Discovery, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.J., S.F.)
Jian Jin
School of Anatomy, Physiology, and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia (P.B.); and Division Chemical Biology and Medicinal Chemistry, and Center for Integrative Chemical Biology and Drug Discovery, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.J., S.F.)
Stephen Frye
School of Anatomy, Physiology, and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia (P.B.); and Division Chemical Biology and Medicinal Chemistry, and Center for Integrative Chemical Biology and Drug Discovery, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.J., S.F.)
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Rapid CommunicationMinireview
Writing and Rewriting the Epigenetic Code of Cancer Cells
Pilar Blancafort, Jian Jin and Stephen Frye
Molecular Pharmacology March 1, 2013, 83 (3) 563-576; DOI: https://doi.org/10.1124/mol.112.080697
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- Article
- Abstract
- Introduction
- The “Language” of Chromatin Modifications
- Interconnections between DNA Methylation and Histone Methylation
- Context-Dependence of the Epigenetic Modifications
- Mechanisms of DNA Demethylation
- Epigenetic Alterations in Cancer
- Strategies to Revert the Epigenetic Landscape of Cancer Cells Using Small Molecules and Engineered Proteins
- Selective Inhibitors of Bromodomains and Methyl-Lysine Readers
- Selective Inhibitors of Protein Lysine Methyltransferases
- Artificial Transcription Factors as Locus-specific Epigenetic Modulators
- ATFs Versus Small Molecule Inhibitors
- Summary
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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