Research ArticleArticle
A Novel Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator Acts at a Unique Site and Confers Stimulus Bias to mGlu5 Signaling
M. J. Noetzel, K. J. Gregory, P. N. Vinson, J. T. Manka, S. R. Stauffer, C. W. Lindsley, C. M. Niswender, Z. Xiang and P. J. Conn
Molecular Pharmacology April 2013, 83 (4) 835-847; DOI: https://doi.org/10.1124/mol.112.082891
M. J. Noetzel
Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., K.J.G., P.N.V., S.R.S., J.S.D., C.W.L., C.M.N., Z.X., P.J.C.), Department of Chemistry (J.T.M., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.)
K. J. Gregory
Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., K.J.G., P.N.V., S.R.S., J.S.D., C.W.L., C.M.N., Z.X., P.J.C.), Department of Chemistry (J.T.M., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.)
P. N. Vinson
Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., K.J.G., P.N.V., S.R.S., J.S.D., C.W.L., C.M.N., Z.X., P.J.C.), Department of Chemistry (J.T.M., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.)
J. T. Manka
Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., K.J.G., P.N.V., S.R.S., J.S.D., C.W.L., C.M.N., Z.X., P.J.C.), Department of Chemistry (J.T.M., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.)
S. R. Stauffer
Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., K.J.G., P.N.V., S.R.S., J.S.D., C.W.L., C.M.N., Z.X., P.J.C.), Department of Chemistry (J.T.M., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.)
C. W. Lindsley
Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., K.J.G., P.N.V., S.R.S., J.S.D., C.W.L., C.M.N., Z.X., P.J.C.), Department of Chemistry (J.T.M., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.)
C. M. Niswender
Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., K.J.G., P.N.V., S.R.S., J.S.D., C.W.L., C.M.N., Z.X., P.J.C.), Department of Chemistry (J.T.M., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.)
Z. Xiang
Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., K.J.G., P.N.V., S.R.S., J.S.D., C.W.L., C.M.N., Z.X., P.J.C.), Department of Chemistry (J.T.M., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.)
P. J. Conn
Department of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery (M.J.N., K.J.G., P.N.V., S.R.S., J.S.D., C.W.L., C.M.N., Z.X., P.J.C.), Department of Chemistry (J.T.M., S.R.S., C.W.L.), Vanderbilt University Medical Center, Nashville, Tennessee; and Drug Discovery Biology, MIPS, Monash University, Parkville, Victoria, Australia (K.J.G.)
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Research ArticleArticle
Novel mGlu5 PAM Confers Stimulus Bias Through a Unique Site
M. J. Noetzel, K. J. Gregory, P. N. Vinson, J. T. Manka, S. R. Stauffer, C. W. Lindsley, C. M. Niswender, Z. Xiang and P. J. Conn
Molecular Pharmacology April 1, 2013, 83 (4) 835-847; DOI: https://doi.org/10.1124/mol.112.082891
Research ArticleArticle
Novel mGlu5 PAM Confers Stimulus Bias Through a Unique Site
M. J. Noetzel, K. J. Gregory, P. N. Vinson, J. T. Manka, S. R. Stauffer, C. W. Lindsley, C. M. Niswender, Z. Xiang and P. J. Conn
Molecular Pharmacology April 1, 2013, 83 (4) 835-847; DOI: https://doi.org/10.1124/mol.112.082891
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